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Scientists find blood biomarker that opens door to CTE diagnosis in living patients

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Ingle, S. (2026, November 14). Scientists find blood biomarker that opens door to CTE diagnosis in living patients. The Guardian. https://www.theguardian.com/sport/2026/nov/14/scientists-find-blood-biomarker-cte-diagnosis-rugby-american-football

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The Guardian · collected 2026-11-14 · by Sean Ingle

Quick Summary

Researchers at Washington University School of Medicine in St. Louis have discovered a blood biomarker, eMTBR-tau243, which could potentially diagnose advanced Chronic Traumatic Encephalopathy (CTE) in living individuals. The study, published in JAMA Neurology, found elevated levels of this protein fragment in individuals later confirmed to have CTE after death, indicating a possible tool for monitoring those at risk. However, the test is not yet validated for diagnosing early-stage CTE.
Written by AI on 2026-11-15, from this article's own text only (the story summary below draws on all the coverage).

AI analysis

Story summary

Scientists at Washington University School of Medicine in St. Louis have identified a blood biomarker, eMTBR-tau243, that could potentially diagnose chronic traumatic encephalopathy (CTE) in living patients. Published in the medical journal JAMA Neurology, the study found that eMTBR-tau243 levels are elevated in individuals with advanced CTE, distinguishing them from healthy people and correlating with the severity of the disease. While the test can reliably identify advanced CTE, it is less effective in detecting early-stage cases. This breakthrough opens new avenues for diagnosing and treating CTE, which is primarily caused by repeated head trauma and is prevalent in collision and contact sports like American football.

Written for “Scientists Discover CTE Blood Biomarker” on 2026-11-15, grounded in this article and the 0 other(s) covering the same event.

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Story

Scientists Discover CTE Blood Biomarker
Science · 1 article(s) covering the same event.
How this article was measured signals, leaning charts, publisher record, byline, topics and claims

Signals How these are calculated →

Claims extracted
16
sentences that state something as happening or true
Uncertain
19%
3 of 16 hedged ("reportedly", "may", "according to")
Leaning
not political
takes no side on a contested political question
Publisher signals
65/100
The Guardian's corrections and hedging, across everything collected from it. Not a measure of accuracy.
Outlets on this story
1
Science
Same framing elsewhere
1
articles that frame the event the way this one does
Analyzed 2026-11-15 · how these are computed

How this is being covered How these are calculated →

Article leaning vs. publisher reliability
Source leaning vs. consistency

Publisher

The Guardian · 2424 article(s) · 7 correction(s) detected
Running correction rate · 7 correction(s)

Who wrote this

Sean Ingle
2 article(s) here · 1 carrying a prediction
Yet while the test could distinguish people with advanced CTE from healthy people with high accuracy, it could not reliably identify early-stage CTE.
Sweeney appeared to respond to the criticism by posting a series of images of prominent female and male athletes posing naked for magazine shoots, including Serena Williams and the footballer Megan Rapinoe and the basketball player Sue Bird.
Also by Sean Ingle
Nothing else under this byline is closely related to this article, so these are simply their most recent.

Topics

American JAMA Neurology NFL St Louis Washington University School of Medicine

Subjects

NFL ORG · 2× American NORP · 1× Chihiro Sato PERSON · 1× Horie PERSON · 1× JAMA Neurology ORG · 1× Junior Seau PERSON · 1× Kanta Horie PERSON · 1× Mike Webster PERSON · 1× St Louis GPE · 1× Washington University School of Medicine ORG · 1×

Narrative

As things stand CTE, which is caused by repeated trauma to the head and is especially prevalent in collision and contact sports such as American football, rugby and football, can be diagnosed only after death by examining brain tissue. However, scientists at Washington University School of Medicine in St Louis have now identified a protein fragment in blood – eMTBR-tau243 – that is elevated not only in Alzheimer’s disease but also in other brain diseases that share the same type of toxic protein buildup, including CTE.
framing: assertive · carried by 1 article(s) · first seen 2026-11-15
Yet while the test could distinguish people with advanced CTE from healthy people with high accuracy, it could not reliably identify early-stage CTE.

Claims (16 extracted, 3 hedged)

Scientists have moved a step closer to diagnosing the degenerative brain condition chronic traumatic encephalopathy in living people, after a study found a blood biomarker that identifies an advanced form of the disease. asserted
that → move → disease
As things stand CTE, which is caused by repeated trauma to the head and is especially prevalent in collision and contact sports such as American football, rugby and football, can be diagnosed only after death by examining brain tissue. However, scientists at Washington University School of Medicine in St Louis have now identified a protein fragment in blood – eMTBR-tau243 – that is elevated not only in Alzheimer’s disease but also in other brain diseases that share the same type of toxic protein buildup, including CTE. asserted
that → stand → CTE
“We are potentially opening a new door for diagnosing and treating CTE in living patients,” said Kanta Horie, the co-senior author of the study in the medical journal JAMA Neurology. asserted
Horie → open → journal
When researchers tested blood from 11 people whose CTE was confirmed at autopsy, they found that levels of eMTBR-tau243 were higher than in healthy people and rose with the severity of the brain disease. asserted
levels → test → disease
Yet while the test could distinguish people with advanced CTE from healthy people with high accuracy, it could not reliably identify early-stage CTE. uncertain
it → distinguish → CTE
The test has not yet been validated for diagnosing CTE. asserted
test → validate → CTE
However, the scientists say that if large studies confirm their findings, clinicians could use such a blood test to monitor people at risk from CTE and enable trials of drugs that could help the condition. uncertain
that → say → condition
“Our study shows that an Alzheimer’s disease biomarker can be applied to other tauopathies, including CTE,” the neuroscientist Chihiro Sato, who co-authored the study with Horie, asserted
- → show → Horie
“This is not going to be a standalone biomarker. asserted
This → go → ?
But if someone has a history of repeated head injury, tests negative for Alzheimer’s and this biomarker comes up, it might be CTE.” uncertain
it → have → Alzheimer
CTE continues to be a major focus of concern across science and sport. asserted
CTE → continue → science
In one recent study of nearly 400 NFL players whose brains were donated for examination after their deaths, 93.5% showed evidence of CTE. asserted
% → donate → CTE
More than 350 NFL players have been diagnosed with CTE after their deaths, including Mike Webster, a hall of fame center; Junior Seau, whose 20-year career included two Super Bowl appearances, and Frank Gifford, who was a former MVP and prominent broadcaster. asserted
who → diagnose → appearances
Legal action is continuing from a number of living former rugby union and league players who have been diagnosed with Traumatic Encephalopathy Syndrome (TES), including the England World Cup winner Steve Thompson. asserted
who → continue → winner
The boxer Ricky Hatton also had a mild CTE diagnosis after his death. asserted
boxer → have → death
Earlier this year, the Professional Footballers’ Association recommended that professionals should not head a ball more than 10 times a week in training sessions, and children under 12 not at all, as part of a CTE prevention protocol. asserted
professionals → recommend → protocol
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