The Aporia
Svoboda, D. (2026, October 11). Lions vs. Cardinals prediction: NFL Week 5 picks, odds, bets. New York Post. https://nypost.com/2026/10/11/betting/lions-vs-cardinals-prediction-nfl-week-5-picks-odds-bets/
Svoboda, Dylan. “Lions vs. Cardinals prediction: NFL Week 5 picks, odds, bets.” New York Post, 11 Oct. 2026, https://nypost.com/2026/10/11/betting/lions-vs-cardinals-prediction-nfl-week-5-picks-odds-bets/.
Svoboda, Dylan. “Lions vs. Cardinals prediction: NFL Week 5 picks, odds, bets.” New York Post, October 11, 2026. https://nypost.com/2026/10/11/betting/lions-vs-cardinals-prediction-nfl-week-5-picks-odds-bets/.
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The Detroit Lions will face the Arizona Cardinals in NFL Week 5 on Sunday. The Lions aim to improve their record after a tough start to the season, currently struggling with one of the league’s worst defenses. Detroit ranks last in opponent EPA per play and 29th in defensive success rate, allowing an NFL-worst 127 points. Despite this, they boast an explosive offense that ranks sixth in EPA per play and third in offensive success rate. The Cardinals have shown their ability to score against quality teams, putting up 30 points against the San Francisco 49ers in Week 3 and 24 points against the New York Giants last week. Given these factors, there is a high likelihood of a high-scoring game, with both sides expected to put up significant points despite their defensive struggles.