A daily pill for Parkinson's disease has demonstrated huge benefits in a late–stage trial, raising hopes patients could see the first major new class of treatment in decades.
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patients → demonstrate → decades
The drug significantly reduced the amount of time patients spent struggling with the stiffness, slowness and tremors associated with the condition.
It also helped them to stay more alert during the day, made everyday tasks such as dressing and eating easier and improved their overall quality of life.
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tasks → reduce → life
The drug, named solengepras, works in a different way to the treatments that have dominated Parkinson's care for more than half a century.
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that → name → century
Most of the medicines doctors currently use act on dopamine, a chemical messenger in the brain that helps control movement and is depleted in people with the disease.
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that → use → disease
But solengepras targets a different part of the brain's movement system, potentially opening a new route for treatment.
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solengepras → target → treatment
Dame Kate Bingham, managing partner at SV Health Investors, whose Dementia Discovery Fund backed Cerevance, the Boston–based biotech company behind the drug, described it as 'an entirely novel drug class beyond the dopamine pathway, which has been the basis of Parkinson's treatment for decades'.
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which → back → decades
About 166,000 people in the UK have been diagnosed with Parkinson's, with thousands more thought to be living with the condition without a diagnosis.
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thousands → diagnose → diagnosis
Dame Kate Bingham, managing partner at SV Health Investors, whose Dementia Discovery Fund backed Cerevance, the Boston–based biotech company behind the drug
The progressive brain condition develops when nerve cells that make dopamine are gradually lost.
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that → back → dopamine
As dopamine levels fall, movements can become slower and stiffer, and a tremor can develop.
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tremor → fall → ?
A treatment called levodopa transformed Parkinson's care in the 1960s.
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treatment → call → 1960s
It is converted by the body into dopamine, helping to replace some of what the brain has lost.
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brain → convert → what
Since then, the most effective treatments have largely worked along the same lines, by boosting dopamine or copying its effects.
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treatments → work → effects
They can be highly effective but as Parkinson's progresses their effects often become less predictable.
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effects → progress → ?
Patients experience what are known as 'off' periods when a dose wears off and symptoms return.
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symptoms → experience → periods
Dopamine–based treatments can also cause dyskinesia, which involves involuntary twisting or jerking movements.
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which → base → movements
Actor Michael J. Fox, who has helped raised the profile of Parkinson's disease by speaking about his own diagnosis
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who → help → diagnosis
Rather than influencing dopamine levels, solengepras blocks a receptor called GPR6, which is found in a brain circuit that acts like a brake on movement.
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that → influence → movement
In Parkinson's, the loss of dopamine upsets the balance between brain signals that encourage movement and those that hold it back.
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that → upset → it
If the brake effect is too strong, solengepras is designed to ease it.
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solengepras → design → it
The Phase 3 trial involved 341 people with Parkinson's, who were randomly assigned to receive either 75mg or 150mg of solengepras, or a placebo, once a day for 12 weeks.
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who → involve → weeks
All the patients enrolled in the trial also continued to take levodopa and other dopamine–based drugs, which were already being prescribed.
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which → enrol → levodopa
Both the patients taking solengepras and those taking the placebo improved over the trial, despite the latter group being given a sham pill.
However, the higher–dose solengepras group experienced about 37 minutes less 'off' time each day – where their dopamine drugs were not working properly – than those taking the placebo, and about 94 minutes less 'off' time than before the trial began.
They also gained about 36 extra minutes a day of 'on' time without troublesome dyskinesia, compared with the placebo group, The Times reported.
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Times → take → group
Furthermore, patients taking solengepras did better on a standard scale measuring activities such as dressing, eating and getting around.
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patients → take → dressing
No serious adverse events were reported and only 3.5 per cent of patients stopped treatment because of side effects, which was the same proportion as in the placebo group.
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which → report → group
Dr Stuart Isaacson, a principal investigator in the trial, said patients often end up taking increasingly frequent and higher doses of levodopa, alongside other dopamine–based drugs.
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patients → say → drugs
As doses rise, so can side effects such as dyskinesia, which prevents many patients from taking the amount they need.
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they → rise → amount
The new treatment could offer a much–needed alternative and 'gives great hope for the future', he added.
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he → offer → future
Laurence Barker, a partner at SV Health Investors and a board member of Cerevance, said: 'We are thrilled to see that the early scientific discovery of GPR6 has now translated to benefit across daily function, alertness, and quality of life measures that will have meaningful impact for Parkinson's patients.
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that → say → patients
The next steps will involve discussions with US health regulators, with talks with UK regulators expected to follow.
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talks → involve → regulators
If everything goes smoothly, the treatment could be available for patients in two to three years.
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treatment → go → years
The Aporia
